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Piwiinteracting rnas pirnas have numerous crucial biological roles, particularly transposon silencing in the germ line. We further show that asz1 is required for proper oogenesis. Ekmom pirna shows high similarity to a region of the zlinked ekmasc genes and is expressed at the onset of female development, suggesting that it is likely the primary trigger of sex determination. Using chromatin profiling and bioinformatic analyses, qu et al.

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